At 2201hrs Co. 1 (Bowling Green), Co.2 (Ladysmith), Co.4 (Sparta), Co.5 (Frog Level),Co.6 (Upper Caroline), and Co. 8 (Fort A. P. Hill) were dispatched for a large residential fire on Devils Three Jump Rd. After Engine 1 w/4 arrived with heavy smoke and fire from the second floor. One firefighter was assaulted when he tried to stop the occupant from running back into the house. After she bit the firefighter, she was detained by the Caroline Sherriffs Office. Once the crews could get to work they were able to contain the fire to the second floor. Wag. 1 w/4 arrived and set up water supply. Eng. 8 w/4 took care of ventilation and Eng.2 w/3 assisted the crews from Engine 1 and Wagon 1 with fire attack. Extensive overhaul was performed and after assisting with the fire investigation Engine 1 returned at 0402hrs. The fire was determined to be arson.